Mycoplasma Pneumoniae-Induced Rash and Mucositis: A Case Report and Literatura Review
DOI:
https://doi.org/10.60591/crspmi.31Keywords:
Erythema Multiforme, Exanthema, Mucositis, Mycoplasma pneumoniae, Pneumonia Mycoplasma, Stevens- Johnson SyndromeAbstract
The dermatological manifestations associated with Mycoplasma pneumoniae are characterized by prominent mucosal involvement and variable skin involvement, usually in the form of a vesiculobullous rash. For a long time, this entity was classified as part of the epidermolytic dermopathies, but in recent years, considering its benign course and distinct morphology, it has been reclassified as a separate disease, called mucositis and rash induced by Mycoplasma pneumoniae.
With this work, the authors present a case that constituted
a diagnostic challenge, due to the difficulty to allocate
this presentation into a clinical syndrome of the Stevens-
-Johnson syndrome (SJS)-toxic epidermolytic necrolysis (TEN)-erythema multiforme (EM) continuum, alerting to the
existence of this new clinical entity.
Downloads
References
Waites KB, Talkington DF. Mycoplasma pneumoniae and its role as a human pathogen. Clin Microbiol Rev. 2004;17:697-728. doi: 10.1128/CMR.17.4.697-728.2004.
Gossart R, Malthiery E, Aguilar F, Torres JH, Fauroux MA. Fuchs Syndrome: Medical Treatment of 1 Case and Literature Review. Case Rep Dermatol. 2017;9:114-20. doi: 10.1159/000468978.
Canavan TN, Mathes EF, Frieden I, Shinkai K. Mycoplasma pneumoniae-induced rash and mucositis as a syndrome distinct from Stevens-Johnson syndrome and erythema multiforme: a systematic review. J Am Acad Dermatol. 2015;72:239-45. doi: 10.1016/j.jaad.2014.06.026.
Frantz GF, McAninch SA. Mycoplasma Mucositis. [Updated 2021 Aug 13]. In: StatPearls [Internet]. Treasure Island: StatPearls Publishing; 2022.
Norton SA. Diagnosing Mycoplasma pneumoniae-induced rash and mucositis (MIRM) in the emergency room. J Am Acad Dermatol. 2015;73:e67. doi: 10.1016/j.jaad.2015.03.060.
Samim F, Auluck A, Zed C, Williams PM. Erythema multiforme: a review of epidemiology, pathogenesis, clinical features, and treatment. Dent Clin North Am. 2013;57:583-96. doi: 10.1016/j.cden.2013.07.001.
Hazin R, Ibrahimi OA, Hazin MI, Kimyai-Asadi A. Stevens-Johnson syndrome: pathogenesis, diagnosis, and management. Ann Med. 2008;40:129-38. doi: 10.1080/07853890701753664.
Martínez-Pérez M, Imbernón-Moya A, Lobato-Berezo A, Churruca-Grijelmo M. Mycoplasma pneumoniae-Induced Mucocutaneous Rash: A New Syndrome Distinct from Erythema Multiforme? Report of a New Case and Review of the Literature. Actas Dermosifiliogr. 2016;107:e47-51. doi: 10.1016/j.ad.2015.09.023.
Chaudhry R, Ghosh A, Chandolia A. Pathogenesis of Mycoplasma pneumoniae: An update. Indian J Med Microbiol. 2016;34:7-16. doi:
4103/0255-0857.174112.
Talkington D, Waites KB, Schwart SB Besser RE. Emerging from Obscurity: Understanding Pulmonary and Extrapulmonary Syndromes, Pathogenesis, and Epidemiology of Human Mycoplasma pneumoniae Infections. In: Scheld WM, Craig WA; Hughes JM, editors: Emerging Infections 5. London: Wiley; 2001. doi: 10.1128/9781555816988.ch4
Amode R, Ingen-Housz-Oro S, Ortonne N, Bounfour T, Pereyre S, Schlemmer F, et al. Clinical and histologic features of Mycoplasma pneumoniae-related erythema multiforme: A single-center series of 33 cases compared with 100 cases induced by other causes. J Am Acad Dermatol. 2018;79:110-7. doi: 10.1016/j.jaad.2018.03.013.
Bressan S, Mion T, Andreola B, Bisogno G, Da Dalt L. Severe Mycoplasma pneumoniae-associated mucositis treated with immunoglobulins. Acta Paediatr. 2011;100:e238-40. doi: 10.1111/j.1651-2227.2011.02342.x.
Li HO, Colantonio S, Ramien ML. Treatment of Mycoplasma pneumoniae-induced rash and mucositis with cyclosporine. J Cutan Med Surg. 2019;23:608-12. doi: 10.1177/1203475419874444.
Downloads
Published
How to Cite
License
Copyright (c) 2024 Bárbara Oliveira, Sara Costa, Juliana Sá, Guilherme Castro Gomes
This work is licensed under a Creative Commons Attribution 4.0 International License.