Hypereosinophilic Syndrome with Skin Involvement: A Mild Case in a Severe Disease
DOI:
https://doi.org/10.60591/crspmi.113Keywords:
Hypereosinophilic Syndrome/diagnosis, Hypereosinophilic Syndrome/drug therapy, Skin/pathologyAbstract
Hypereosinophilic syndromes are a group of rare disorders defined by the association of peripheral blood eosinophilia (absolute eosinophil count >1.5 x 109/L) on two examinations taken at least one month apart, eosinophil-mediated organ damage and/or dysfunction, with exclusion of other potential causes.
We present a case of an 89-year-old woman with purpuric lesions on both legs, beginning the past few months. Physical examination revealed multiple scattered purpuric macules in the lower limbs and diagnostic work-up showed eosinophilia (19.82 x 109/L) and high immunoglobulin E (709 U/L) without any remarkable other change. Skin biopsy showed superficial dermis with moderate number of eosinophils, suggestive of hypereosinophilic syndrome. The patient was treated with prednisolone 1 mg/kg for six days, presenting quick resolution of eosinophilia, without worsening after corticosteroid taper.
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