Parvovirus B19 Infection in an Immunocompromised Patient: Case Report
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https://doi.org/10.60591/crspmi.141Keywords:
Anemia, Immunocompromised Host, Parvoviridae Infections, Parvovirus B19, HumanAbstract
Parvovirus B19 infection (fifth disease) is common during
childhood. In adults, symptoms of parvovirus B19 infection
depend on patients’ immune and hematologic status. Immunocompetent adults present with influenza-like symptoms and arthralgia. In patients with anemia, transient aplastic crisis and severe anemia may happen. In immunodeficiency states, chronic anemia is common. We report a case of an immunocompromised patient with acute parvovirus B19 infection. She presented with gradual dyspnea, asthenia, fever and diarrhea for few months, which got worse in the previous week. Laboratory investigations revealed hypoproliferative anemia. Afterwards, there were symptoms of heart failure, despite normal echocardiography. Serologic studies revealed anti B19 IgM in the absence of IgG antibody. Hence, we assumed acute parvovirus B19 infection. With supportive treatment, clinical response and hematologic recovery took place. Diagnosis of parvovirus B19 infection in adults requires high index of suspicion and should be considered
towards a patient with unexplained hypoproliferative anemia.
References
Heegaard ED, Brown KE. Human parvovirus B19. Clin Microbiol Rev.2002;15:485-505. doi: 10.1128/CMR.15.3.485-505.2002.
Landry ML. Parvovirus B19. Microbiol Spectr. 2016;4. doi: 10.1128/microbiolspec.
Young NS, Brown KE. Parvovirus B19. N Engl J Med. 2004;350:586-97. doi: 10.1056/NEJMra030840.
Rogo LD, Mokhtari-Azad T, Kabir MH, Rezaei F. Human parvovirus B19: a review. Acta Virol. 2014;58:199-213. doi: 10.4149/av_2014_03_199.
Yetgin S, Aytaç Elmas S. Parvovirus-B19 and hematologic disorders. Turk J Haematol. 2010;27:224-33. doi: 10.5152/tjh.2010.43.
Garcia O, Pereira J, Godoy T, Sanabani S, Neto K, Sabino C. Hematologic diseases associated with eritrovirus. Rev Bras Hematol Hemoterap. 2009;31: 285-90.
Kaneko H, Shimura K, Nishida K, Fujiwara Y, Matsumoto Y, Kuroda J, et al. Pure red cell aplasia caused by parvovirus B19 in two patients without chronic hemolysis. J Infect Chemother. 2011;17:268-71. doi: 10.1007/s10156-010-0106-0.
Schultheiss HP, Baumeier C, Pietsch H, Bock CT, Poller W, Escher F. Cardiovascular consequences of viral infections: from COVID to other viral diseases. Cardiovasc Res. 2021;117:2610-23. doi: 10.1093/cvr/cvab315.
Molina KM, Garcia X, Denfield SW, Fan Y, Morrow WR, Towbin JA, et al. Parvovirus B19 myocarditis causes significant morbidity and mortality in children. Pediatr Cardiol. 2013;34:390-7. doi: 10.1007/s00246-012-0468-4.
Alberti L, Loffi M, Fragasso G, Spoladore R, Ballarotto C, Margonato A. Acute heart failure caused by parvovirus B-19 myocarditis treated with human immunoglobulin. Case Rep Cardiol. 2012;2012:180871. doi: 10.1155/2012/180871.
Saint-Martin J, Choulot JJ, Bonnaud E, Morinet F. Myocarditis caused by parvovirus. J Pediatr. 1990;116:1007-8. doi: 10.1016/s0022-
(05)80677-8.
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Copyright (c) 2024 Sofia Esteves, Francisco Capinha, João Luís Cavaco, Ana Furão Rodrigues, Ana Júlia Oliveira Pedro
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