Creutzfeldt-Jakob Disease in an Internal Medicine Ward: A Case Series
Doença de Creutzfeldt-Jakob numa Enfermaria de Medicina: Uma Série de Casos
DOI:
https://doi.org/10.60591/crspmi.249Palavras-chave:
Acitretin; Creutzfeldt-Jakob Syndrome/blood, Creutzfeldt-Jakob Syndrome/diagnosis, Creutzfeldt-Jakob Syndrome/diagnostic imaging, 14-3-3 ProteinsResumo
Creuztfeldt-Jakob disease (CJD) is a rare and fatal prion neurogenerative disease that affects humans and other mammals, with a global prevalence of 1: million habitants. It occurs mainly between the ages of 50 and 70 and is characterized by rapidly progressive dementia. It is divided into 3 main forms: sporadic, genetic, and acquired. The definitive diagnosis is made through anatomopathological examination of the brain, although a highly probable diagnosis can be made through clinical criteria and complementary diagnostic tests.
We present three clinical cases of CJD diagnosed in a Hospital Unit. The average age was 61 years old, and all presented initial behavioral symptoms. The mortality rate was 100% with anatomopathological examination, which confirmed the diagnosis of sporadic Creutzfeldt-Jakob disease.
Rapidly progressive dementia with atypical signs/symptoms should be investigated. Although rare, the sporadic form has been increasing, meaning greater attention and recognition are needed.
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Direitos de Autor (c) 2024 Rita Serejo Portugal, Maria Helena F. Silva, André Matos Gonçalves, Ana Rita Sanches, Sónia Cunha Martins, Margarida Sousa carvalho
Este trabalho encontra-se publicado com a Licença Internacional Creative Commons Atribuição 4.0.
