Capecitabine-Induced Terminal Ileitis: Review of the Literature After a Case Report

Authors

  • Carolina Amado Serviço de Medicina Interna do Centro Hospitalar do Baixo Vouga, Aveiro, Portugal
  • Ana Rocha Oliveira Serviço de Medicina Interna do Centro Hospitalar do Baixo Vouga, Aveiro, Portugal https://orcid.org/0000-0002-7061-8127
  • Bárbara Paracana Serviço de Medicina Interna do Centro Hospitalar do Baixo Vouga, Aveiro, Portugal https://orcid.org/0009-0004-3145-9671
  • Laura Baptista Serviço de Medicina Interna do Centro Hospitalar do Baixo Vouga, Aveiro, Portugal
  • Gisela Gonçalves Serviço de Medicina Interna do Centro Hospitalar do Baixo Vouga, Aveiro, Portugal
  • Margarida Cruz Serviço de Medicina Interna do Centro Hospitalar do Baixo Vouga, Aveiro, Portugal

DOI:

https://doi.org/10.60591/crspmi.39

Keywords:

Capecitabine/adverse effects, Ileitis/chemically induced

Abstract

Capecitabine is an oral fluropyrimidine used as palliative
chemotherapy in colorectal and breast cancer patients. Diarrhea is a well-known side effect of capecitabine, being ileitis cases rare. The authors present a case of a terminal ileitis as a late iatrogenic effect of capecitabine treatment.

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References

Nicosia L, Russo I, De Sanctis V, Minniti G, Valeriani M, Osti MF. Two Cases of Capecitabine-Induced Ileitis in Patients Treated with Radiochemotherapy to the Pelvis and Review of the Literature. J Gastrointest Cancer. 2018;49:538-42. doi: 10.1007/s12029-017-9955-4.

Dao AE, Hsu A, Nakshabandi A, Mandaliya R, Nadella S, Sivaraman A,et al. Role of colonoscopy in diagnosis of capecitabine associated

ileitis: Two case reports. World J Gastrointest Endosc. 2019 May 16;11(5):383-388. doi: 10.4253/wjge.v11.i5.383.

Radwan R, Namelo WC, Robinson M, Brewster AE, Williams GL. Ileitis secondary to oral capecitabine treatment? Case Rep Med.

;2012:154981. doi: 10.1155/2012/154981.

van Hellemond IE, Thijs AM, Creemers GJ. Capecitabine-associated terminal ileitis. Case Rep Oncol. 2018;11:654-9. doi:

1159/000492781.

Klimko A, Tieranu CG, Olteanu AO, Preda CM, Ionescu EM. Capecitabina-induced terminal ileitis: Case report and literature review.

Cureus.2021;13:e14621. doi: 10.7759/cureus.14621.

Lam SW, Guchelaar HJ, Boven E. The role of pharmacogenetivs in capecitabine efficacy and toxicity. Cancer Treat Rev. 2016;50:9-22. doi: 10.1016/j.ctrv.2016.08.001.

Lee SF, Chiang CL, Lee AS, Wong FC, Tung SY. Severe ileitis associated with capecitabine: two case reports and review of the literature.

Mol Clin Oncol. 2015, 3:1398-400. doi: 10.3892/mco.2015.635.

Mokrim M, Aftimos PG, Errihani H, Piccart-Gebhart M. Breast cancer, DPYD mutations and capecitabine related ileitis: description

of two cases and a review of the literature. BMJ Case Rep. 2014;2014:bcr2014203647. doi: 10.1136/bcr-2014-203647.

Al-Gahmi AM, Kerr IG, Zekri JM, Zagnoon AA. Capecitabine-induced terminal ileitis. Ann Saudi Med. 2012;32:661-2. doi: 10.5144/0256-

2012.661.

European Medicines Agency. EMA recommendations on DPD testing prior to treatment with fluoracil, capecitabine, tegafur and flucytosine. EMA/229267/2020. [Jan 2023] Available from: https://www.ema.europa. eu/en/news/ema-recommendations-dpd-testing-prior-treatment-fluorouracil-capecitabine-tegafur-flucytosine

Alterações arquiteturais da mucosa ileal, com infiltrado inflamatório agudo e microabcesso central, sem evidência de microorganismos (coloração PAS).

Published

26-02-2024

How to Cite

Amado, C., Rocha Oliveira, A., Paracana, B., Baptista, L., Gonçalves, G., & Cruz, M. (2024). Capecitabine-Induced Terminal Ileitis: Review of the Literature After a Case Report. SPMI Case Reports, 2(1), 8–12. https://doi.org/10.60591/crspmi.39