Non-Hodgkin’s Lymphoma with Uterine Cervix Involvement
DOI:
https://doi.org/10.60591/crspmi.88Keywords:
Cervix Uteri;, Lymphoma, Large B-Cell, Diffuse/diagnosis, Lymphoma, Large B-Cell, Diffuse/drug therapy, Uterine Cervical NeoplasmsAbstract
Lymphomas involving the uterine cervix are very rare. We
report a case of a 71-year-old woman presenting with symptoms of diverticulitis, with various incidental imaging findings suggesting a lymphoproliferative disease and a big cervix mass. Deep uterine cervix biopsy diagnosed a diffuse large B cell lymphoma involving the uterine cervix, presumably
transformed from a marginal zone lymphoma. The patient is
currently under treatment with rituximab, cyclophosphamide,
doxorubicin, vincristine and prednisolone and high-dose methotrexate to central nervous system involvement prophylaxis. To accurately diagnose a uterine cervix non-Hodgkin’s lymphoma, the medical team must be aware of this clinical diagnostic hypothesis in order to provide the best conditions to the work-up, like a deep uterine cervix biopsy and histological and immunohistochemical studies of the sample.
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References
Cubo AM, Soto ZM, Cruz MA, Doyague MJ, Sancho V, Fraino A, et al. Primary diffuse large B cell lymphoma of the uterine cervix successfully treated by combined chemotherapy alone: A case report. Medicine. 2017;96:e6846. doi: 10.1097/MD.0000000000006846
Miura LY, Maure MAD, Zomer MT, Ribeiro R, Cavalcanti TCS, Kondo W. A Case of Primary Uterina Lymphoma Presenting with Bleeding, Pelvic Pain, and Dysmenorrhea. Case Rep Obstet Gynecol. 2018;2018:5065738. doi: org/10.1155/2018/5065738
Sharma V, Dora T, Patel M, Sancheti S, Sridhar E. Case Report of Diffuse Large B Cell Lymphoma of Uterine Cervix Treated at a Semiurban Cancer Centre in North India. Case Rep Hematol. 2016;2016:3042531. doi: 10.1155/2016/3042531
Vang R, Medeiros LJ, Ha CS, Deavers M. Non-Hodgkin's Lymphomas Involving the Uterus: A Clinicopathologic Analysis of 26 Cases. Mod Pathol. 2000;13:19–28. doi: 10.1038/modpathol.3880005
Mandato VD, Palermo R, Falbo A, Capodanno I, Capodanno F, Gelli MC, et al. Anticancer Res. 2014;3:4377-90.
Li J, Zhang X, Liu Y, Li Q, Guo Y, Yu H. Primary diffuse large B-Cell lymphoma of the uterine cervix with severe lower urinary tract Symptoms: A rare case report and review of the literature. Gynecol Oncol Rep. 2022;43:101066. doi: 10.1016/j.gore.2022.101066.
Saxena A, Murray RB, Olatunbosun OA, Saxena M, Maksymiuk AW. Non-Hodgkin’s Lymphoma of the Uterine Corpus simulating Uterine Sarcoma. J Soc Obstet Gynaecol Can. 1998;20:884-8. doi: 10.1016/S0849-5831(16)30832-1
- Onyiuke I, Kirby AB, McCarthy S. Primary Gynecologic Lymphoma: Imaging Findings. AJR. 2013;201:W648-W655. doi:10.2214/AJR.12.8907
Ensor AM, Sanchez CG, Ensor JE, Anand K. Primary diffuse large B-cell lymphoma of the uterus: a SEER database analysis. Medicine. 2021;100:40. doi: 10.1097/MD.0000000000027359
Maeshima AM, Taniguchi H, Toyoda K, Yamauchi N, Makita S, Fukuhara S, et al. Clinicopathological features of histological transformation from extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue to diffuse large B-cell lymphoma: an analysis of 467 patients. Br J Haematol. 2016;174:923-31. doi: 10.1111/bjh.14153
Conconi A, Franceschetti S, Aprile von Hohenstaufen K, Margiotta-Casaluci G, Stathis A, Moccia AA, et al. Histologic transformation in marginal zone lymphomas. Ann Oncol. 2015;26:2329-35. doi: 10.1093/annonc/mdv368
The International Non-Hodgkin's Lymphoma Prognostic Factors Project. A Predictive Model for Aggressive Non-Hodgkin's Lymphoma. N Engl J Med. 1993;329:987-94.
Ziepert M, Hasenclever D, Kuhnt E, Glass B, Schmitz N, Pfreundschuh M, et al. Standard International Prognostic Index remains a valid predictor of outcome for patients with aggressive CD20+ B-cell lymphoma in the rituximab era. J Clin Oncol. 2010;28:2373-80. doi: 10.1200/JCO.2009.26.2493
