Leukocytoclastic Vasculitis: A Rare Paraneoplastic Phenomenon in Ovarian Tumor
DOI:
https://doi.org/10.60591/crspmi.8Keywords:
Ovarian Neoplasms, Paraneoplastic Syndromes, Vasculitis, Leukocytoclastic, CutaneousAbstract
Leukocytoclastic vasculitis (LCV) is an inflammatory process of small-sized vessels, most often secondary to a specific pathology, but its association with solid malignancies is rarely described.
We report a case of a 75-year-old female patient who presented with erythematous macules and palpable purpura affecting her limbs, whose skin biopsy revealed LCV, as a solitary manifestation of a later diagnosed ovarian neoplasm. Despite the improvement of cutaneous vasculitis with corticosteroids, even without total resolution, only the treatment of the underlying malignancy, for which the patient had no clinical conditions, could resolve the entire condition.
To our knowledge only 1 case of a paraneoplastic LCV has been reported in the context of an ovarian neoplasm.
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References
Fraticelli P, Benfaremo D, Gabrielli A. Diagnosis and management of leukocytoclastic vasculitis. Intern Emerg Med. 2021;16:831-41. doi: 10.1007/s11739-021-02688-x.
Blanco R, Martínez-Taboada VM, Rodríguez-Valverde V, García-Fuentes M. Cutaneous vasculitis in children and adults. Associated diseases and etiologic factors in 303 patients. Medicine. 1998;77:403-18. doi: 10.1097/00005792-199811000-00007.
Loricera J, Calvo-Río V, Ortiz-Sanjuán F, González-López MA, Fernández-Llaca H, Rueda-Gotor J, et al. The spectrum of paraneoplastic cutaneous vasculitis in a defined population: incidence and clinical features. Medicine. 2013;92:331-43. doi: 10.1097/MD.0000000000000009.
Stashower ME, Rennie TA, Turiansky GW, Gilliland WR. Ovarian cancer presenting as leukocytoclastic vasculitis. J Am Acad Dermatol. 1999;40:287-9. doi: 10.1016/s0190-9622(99)70466-4
Greer JM, Longley S, Edwards NL, Elfenbein GJ, Panush RS. Vasculitis associated with malignancy. Experience with 13 patients and literature review. Medicine. 1988;67:220-30. doi: 10.1097/00005792-198807000-00003.
