Immune Thrombocytopenic Purpura After SARS-CoV-2 Moderna® Vaccine: A Case Study
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https://doi.org/10.60591/crspmi.146Keywords:
2019-nCoV Vaccine mRNA-1273, COVID-19 Vaccines/ adverse effects, COVID-19, Purpura, Thrombocytopenic, Idiopathic/chemically induced, SARS-CoV-2Abstract
condition in which pathogenic antibodies bind to platelets,
accelerating their elimination from the circulation. This case
is about a 65-year-old woman with fatigue, myalgias and localized purpura on the legs, with onset of signs and symptoms 2 days after vaccination. One month earlier, the platelet count was 157x10^9/L. On admission, platelet count was 5x10^9/L, with severe thrombocytopenia confirmed on peripheral blood smear. She was given prednisolone 1 mg/kg/day. After 7 days, the platelet count was 45x10^9/L with resolution of symptoms. Autoimmunity studies, thyroid hormones, coagulation, protein electrophoresis and serological tests were normal. A cause-effect relationship between vaccination and the onset of clinical symptoms was considered probable. INFARMED considered the relationship with the Moderna® vaccine to be probable, as this was the first case in Portugal.
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