Gastric Cancer with Disseminated Bone Marrow Carcinomatosis Initially Presenting with Paraneoplastic Abducens Nerve Palsy

Parésia Paraneoplásica do Nervo Abducente como Apresentação Inicial de Cancro Gástrico com Metastização para a Medula Óssea

Authors

  • Tatiana Pacheco Gastroenterology Department, Unidade Local de Saúde Tâmega e Sousa, Penafiel, Portugal
  • Ana Pacheco Internal Medicine Department, Unidade Local de Saúde Tâmega e Sousa, Penafiel, Portugal
  • Susana Teixeira Internal Medicine Department, Unidade Local de Saúde Tâmega e Sousa, Penafiel, Portugal
  • Mafalda Ferreira Internal Medicine Department, Unidade Local de Saúde Tâmega e Sousa, Penafiel, Portugal
  • Lindora Pires Internal Medicine Department, Unidade Local de Saúde Tâmega e Sousa, Penafiel, Portugal

DOI:

https://doi.org/10.60591/crspmi.185

Keywords:

Abducens Nerve Diseases/complications, Neoplasm Metastasis, Neoplasms, Stomach Neoplasms, Stroke

Abstract

Patients with cancer have a substantially increased risk of stroke, generally related to cancer-associated hyper¬coagulation.1-6 However, gastric cancer is not consistently listed as one of the cancers with the highest risk of stroke.4,7,8

Cancer-related cerebral embolism was never reported
in the literature as a cause of an isolated abducens palsy.
Generally, mononeuropathy of the abducens nerve in cancer patients is associated with tumor compression, increased intracranial pressure, or metastasis.9,10

Bone marrow is a rare local for metastasis in gastric cancer
and its co-occurence with embolic phenomena as initial
presentation is even rarer.11

We describe a rare case of unilateral abducens nerve
palsy associated with metastasized gastric carcinoma to
bone marrow.

Downloads

Download data is not yet available.

References

Kneihsl M, Enzinger C, Wünsch G, Khalil M, Culea V, Urbanic-Purkart T, et al. Poor short-term outcome in patients with ischaemic stroke and active cancer. J Neurol. 2016;263:150–6. doi:10.1007/s00415-015-7954-6

Navi BB, Reiner AS, Kamel H, Iadecola C, Okin PM, Elkind MSV, et al. Risk of Arterial Thromboembolism in Patients with Cancer. J Am Coll Cardiol. 2017;70:926–38. doi: 10.1016/j.jacc.2017.06.047

Salazar-Camelo RA, Moreno-Vargas EA, Cardona AF, Bayona-Ortiz HF. Ischemic stroke: A paradoxical manifestation of cancer. Crit Rev in Oncol Hematol. 2021; 157:103181. doi: 10.1016/j.critrevonc.2020.103181

J. Schwarzbach C, Schaefer A, Ebert A, Held V, Bolognese M, Kablau M, et al. Stroke and cancer: the importance of cancer-associated hypercoagulation as a possible stroke etiology. Stroke. 2012;43:3029–34. doi: 10.1161/STROKEAHA.112.658625

Uemura J, Kimura K, Sibazaki K, Inoue T, Iguchi Y, Yamashita S. Acute stroke patients have occult malignancy more often than expected. Eur Neurol. 2010;64:140–4. doi: 10.1159/000316764

Stefan O, Vera N, Otto B, Heinz L, Wolfgang G. Stroke in cancer patients:A risk factor analysis. J Neurooncol. 2009;94:221–6. doi: 10.1007/s11060-009-9818-3

Lindvig K, Mosbech J, Möller-Jensen O, Möller H. The pattern of cancer in a large cohort of stroke patients. Int J Epidemiol. 1990;19:498–504. doi: 10.1093/ije/19.3.498

Navi BB, Reiner AS, Kamel H, Iadecola C, Elkind MSV, Panageas KS, et al. Association between incident cancer and subsequent stroke. Ann Neurol. 2015;77:291–300. doi: 10.1002/ana.24325

Kung NH, van Stavern GP. Isolated Ocular Motor Nerve Palsies. Semin Neurol. 2015; 35:539-48. doi 10.1055/s-0035-1563568

Elder C, Hainline C, Galetta SL, Balcer LJ, Rucker JC. Isolated Abducens Nerve Palsy: Update on Evaluation and Diagnosis. Curr Neurol Neurosci Rep. 2016;16:69. doi: 10.1007/s11910-016-0671-4

Iguchi H. Recent aspects for disseminated carcinomatosis of the bone marrow associated with gastric cancer: What has been done for the past, and what will be needed in future?. World J Gastroenterol. 2015; 21:12249-60. doi: 10.3748/wjg.v21.i43.12249

Saffra N, Kaplow E, Mikolaenko I, Kim A, Rubin B, Jafar J. Isolated sixth cranial nerve palsy as the presenting symptom of a rapidly expanding ACTH positive pituitary adenoma: A case report. BMC Ophthalmol. 2011;11:4. doi:10.1186/1471-2415-11-4

Souayah N, Krivitskaya N, Huey-Jen L. Lateral rectus muscle metastasis as the initial manifestation of gastric cancer. J Neuroophthalmol. 2008;28:240–1. doi:10.1097/WNO.0b013e318177253a

Rohani N, Mortensen P, Lee AG. Fascicular sixth nerve palsy as a presenting sign of metastatic ovarian carcinoma. J Neuroophthalmol. 2021;41:e372–e374. doi:10.1097/WNO.0000000000001188

Kinori M, Bassat I ben, Huna-Baron R. Sixth nerve palsy as the presenting symptom of metastatic colon carcinoma. Int Ophthalmol. 2011;31:69–72. doi:10.1007/s10792-010-9408-6

Gon Y, Okazaki S, Terasaki Y, Sasaki T, Yoshimine T, Sakaguchi M, et al. Characteristics of cryptogenic stroke in cancer patients. Ann Clin Transl Neurol. 2016; 3:280–7. doi:10.1002/acn3.291

Navi BB, Kasner SE, Elkind MSV, Cushman M, Bang OY, Deangelis LM. Cancer and Embolic Stroke of Undetermined Source. Stroke.

;52:1121-30. doi: 10.1161/STROKEAHA.120.032002

Kaur H, Sasapu A, Ramos J, Govindarajan R. An unusual case of gastric cancer with bone marrow metastases and embolic phenomena as initial presentation. J Gastrointest Cancer. 2015;46:413–6. doi: 10.1007/ s12029-015-9714-3

Kim HS, Yi SY, Jun HJ, Lee J, Park JO, Park YS, et al. Clinical outcome of gastric cancer patients with bone marrow metastases. Oncology. 2008;73:192–7. doi: 10.1159/000127386

Ergun Y. Gastric cancer patients with bone marrow metastasis: a single-center experience and review of the literature. Eurasian J Med Oncol. 2017;1:160-3. doi:10.14744/ejmo.2017.65365

Axial FLAIR-weighted brain magnetic resonance images – (A) Evidence of a left parietal subcortical hypersignal focus (arrow). (B) Evidence of a left posterior periventricular hypersignal focus (arrow).

Downloads

Published

26-09-2024

How to Cite

Pacheco, T., Pacheco, A., Teixeira, S., Ferreira, M., & Pires, L. (2024). Gastric Cancer with Disseminated Bone Marrow Carcinomatosis Initially Presenting with Paraneoplastic Abducens Nerve Palsy: Parésia Paraneoplásica do Nervo Abducente como Apresentação Inicial de Cancro Gástrico com Metastização para a Medula Óssea. SPMI Case Reports, 2(3), 103–108. https://doi.org/10.60591/crspmi.185

Issue

Section

Casos Clínicos

Categories